Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. So the following month we tried Interceptor Plus and it was fine. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Simparica. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. Thank you for the warning. Happy to help! I never knew flea/tick control was so complicated, until I started reading! . Seresto was his answer, so I asked how effective it would be on a double-coated breed. Thank you for all the research, it was all so helpful. I am going to try WonderCide as recommended by my Vet for fleas. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) That indicates it is a strong chemical compound, so do watch for skin irritation. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. Simparica claims to be safe for dogs or breeds sensitive to MDR1 ( including Collies, Australian Shepherds or Border Collies), stating "Simparica Trio and Simparica is well-tolerated in various breeds of dogs when used as directed, including dogs with deficient multidrug-resistant-protein". If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. We will get her in about 3 weeks. . (More on those later.). I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Thank you for the positive feedback. Im leaning toward Frontline Plus based on what you wrote. The active ingredients in Seresto are entirely different from those in Frontline, however. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. Simparica TRIO requires a prescription from your veterinarian. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. We can eat it. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. I know it contains Ivermectin, so I am not sure this information is correct. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. Thanks. My two cats were father and son so probably carried the same gene. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. Last year I used Frontline Plus with no issues. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. It provides 100% protection from heartworm disease. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. Unacceptable for me) He is MDR1 clear. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. Natural Chemistry claims to kill on contact and to be safe for puppies. Based on your recommendations, I will not use Vectra. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. What are your thoughts on that? , Emily, thanks for a very helpful and informative article. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. Rev. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. Use of those drugs can cause serious neurological illness or death. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. The oral chew contains a specially optimised trio of ingredients for . Happy to be of help! There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Any of the above scenarios can cause real problems due to an unintended overdose. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. What do you know about this? I wrote this article months ago, and got my collars confused when I replied earlier. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. Im sincerely grateful!! We are waiting for the results from her test for the MDR1 gene. On the down side, it does not cover any ticks. I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. Is Frontline Plus still safe? So tick protection is also a must for us. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. . The 10 Best Ways to Get Rid of & Prevent Ticks on Dogs. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. Positive feedback keeps me writing! I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Hi Emily If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). Hi, Thank you for this helpful article. After her first heat she went into a false pregnancy. The best thing about Seresto is how long it can do its job up to 8 months! Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. You might want to look at the information on Nexgard. Grupo de perros 1x, 3x y 5x veces la dosis. 5 types of ticks (the only proven chewable for most type of ticks elimination) Eur. Australian Shepherds have a slightly lower incidence, with 50% being affected . - It is easy to administer, with no need for pre-treatment or fasting. Hi Emily, do you know if panacure is a safe wormer? Personally, I would be concerned about missing a daily dose. We have an 11 year old tricolor rough coat collie. For my Aussie mix, Ive had success using Advantix II. It sounds similar to a couple other natural oil products Ive tried. Please let me know how the Wondercide works for you! As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Your article was appreciated and helpful! Hi Emily, Two years ago he tested positive for lyme disease and was treated with antibiotics. This year she has a very high degree of irritation when applied (I had to wash it off). As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. Thanks. Super useful research. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. Doses used for heartworm prevention are safe to use in these breeds of dogs. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient Also, it is not recommended for use with other medications. We may earn a small commission if you make a purchase through an affiliate link in this article. 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